Cyclosporin and low sorbing tubing

[Claire Rickard]

HI Big Brains

I know this is a bit off topic, but can anyone please help me on this? It
is driving us nuts here.

1. Where can one see the DATA on WHY we use low sorbing infusion tubing for
cyclosporin infusion? (I know the theory, just would like to see the proof
:o)) How does absorption vary with dose, rate, time etc?

2. We want to extend use of this tubing for a week instead of 4 days (This
would bring it in line with the other infusions).

A colleague believes that the low sorbing tubing would no longer work after
X number of days (in this case 4), and therefore if we extend it, the
tubing may no longer present absorption.

Yes we have asked the Drug Information Dept and they could not provide any
data on this.

Thinking of running some tests ourselves with a friendly biochemist if we
can’t get a better answer!

Best regards, Claire

*Professor Claire Rickard RN PhD*
c.rickard@griffith.edu.au | +61 7 3735 6460 | Skype: clairexm1 | Twitter:
IVAD_Research |
http://www.griffith.edu.au/health/centre-health-practice-innovation/research/acute-critical-care/intravascular-devices

Intravascular Access Device Research Group | NHMRC Centre of Research
Excellence in Nursing Interventions | Griffith Health Institute | Visiting
Prince Charles Hospital

Research frequently takes me off campus. Please contact Jenny Chan 3735
5406 *j.chan@griffith.edu.au* or
Jo.Wright@griffith.edu.au 3735 4886 with any urgent enquiries.

*It’s nice to be important, but it’s more important to be nice. John Cassis.
*

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[Roel Castillo]

Hi Prof

Apologies, I don’t have a big brain. I believe it is more on the IFU (instructions for use). The device limitations/functionality are not stipulated but clearly exceeding recommended usage would be a legal liability when things go wrong. As we all know, tests were done ( in vitro) in company labs, as a requisite to TGA or FDA approval, the irony that continues to be a challenge to the clinical setting (as they are never tested in real working environment). With all due respect, it is sensible to follow device manufacturer’s IFU, the information being available to end user, covers their part of liability. The important aspect of it is obviously patient safety, for a few dollars more.

Always happy to know the results of your tests if it proves the manufacturer’s claim or otherwise.

Cheers
Roel

Roel Castillo
Project Officer SSD
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HI Big Brains

I know this is a bit off topic, but can anyone please help me on this? It is driving us nuts here.

1. Where can one see the DATA on WHY we use low sorbing infusion tubing for cyclosporin infusion? (I know the theory, just would like to see the proof :o)) How does absorption vary with dose, rate, time etc?

2. We want to extend use of this tubing for a week instead of 4 days (This would bring it in line with the other infusions).

A colleague believes that the low sorbing tubing would no longer work after X number of days (in this case 4), and therefore if we extend it, the tubing may no longer present absorption.

Yes we have asked the Drug Information Dept and they could not provide any data on this.

Thinking of running some tests ourselves with a friendly biochemist if we can’t get a better answer!

Best regards, Claire

Professor Claire Rickard RN PhD
c.rickard@griffith.edu.au | +61 7 3735 6460 | Skype: clairexm1 | Twitter: IVAD_Research |
http://www.griffith.edu.au/health/centre-health-practice-innovation/research/acute-critical-care/intravascular-devices

Intravascular Access Device Research Group | NHMRC Centre of Research Excellence in Nursing Interventions | Griffith Health Institute | Visiting Scholar: Royal Brisbane & Women’s Hospital | Princess Alexandra Hospital | The Prince Charles Hospital

Research frequently takes me off campus. Please contact Jenny Chan 3735 5406 j.chan@griffith.edu.au or Jo.Wright@griffith.edu.au 3735 4886 with any urgent enquiries.

It’s nice to be important, but it’s more important to be nice. John Cassis.
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