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Aspirating blood prior to accessing central line

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  • #74721
    sonja wegert
    Participant

    Author:
    sonja wegert

    Email:
    sonja.wegert@NT.GOV.AU

    Organisation:

    State:

    Hello,

    We are reviewing our central line management policies and we trying to find evidence related to the routine practice for aspiration of blood prior to accessing the central line (especially PICC).
    Our ICU team states that this is routinely performed within oncology groups.

    I would be grateful for some specialist information.

    Kind Regards
    Sonja

    Sonja Wegert | Infection Control Practitioner (ICP)
    Infection Prevention and Control Unit | Central Australia Health Service
    Northern Territory Government
    Alice Springs Hospital, Gap Rd, Alice Springs
    GPO Box 2234, Suburb, NT Postcode
    p … 08 89517977
    e … sonja.wegert@nt.gov.au http://www.nt.gov.au/health

    MESSAGES POSTED TO THIS LIST ARE SOLELY THE OPINION OF THE AUTHOR, AND DO NOT REPRESENT THE OPINION OF ACIPC.

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    #74722
    Michael Wishart
    Participant

    Author:
    Michael Wishart

    Email:
    Michael.Wishart@svha.org.au

    Organisation:

    State:
    NSW

    Hi Sonja

    I can’t say that I am an expert in this area, but in our PICC policy it states this:

    If the PICC has not been accessed for 7 days access the PICC with an empty 10ml syringe. Remove 5mls of blood and discard. Then flush with Normal saline 10mls.

    Not sure exactly why that is in there, as our PICC policy is based on The Queensland Health PICC guidelines (https://www.health.qld.gov.au/__data/assets/pdf_file/0028/444493/icare-pcvc-guideline.pdf) and I cannot see this statement in there.

    Not sure if this helps or not!

    Cheers
    Michael

    Michael Wishart, CICP-E
    Infection Control Coordinator

    A 627 Rode Road, Chermside QLD 4032
    P (07) 3326 3068 | F (07) 3607 2226 | E michael.wishart@svha.org.au | W http://www.hsnph.org.au
    [cid:image001.png@01D01926.61F1C2B0] [cid:image002.png@01D42997.357FB770]
    P Please consider the environment before printing this email

    Hello,

    We are reviewing our central line management policies and we trying to find evidence related to the routine practice for aspiration of blood prior to accessing the central line (especially PICC).
    Our ICU team states that this is routinely performed within oncology groups.

    I would be grateful for some specialist information.

    Kind Regards
    Sonja

    Sonja Wegert | Infection Control Practitioner (ICP)
    Infection Prevention and Control Unit | Central Australia Health Service
    Northern Territory Government
    Alice Springs Hospital, Gap Rd, Alice Springs
    GPO Box 2234, Suburb, NT Postcode
    p … 08 89517977
    e … sonja.wegert@nt.gov.au http://www.nt.gov.au/health

    ______________________________________________________________________
    This email and any attachments to it (the “Email”) is confidential and is for the use only of the intended recipient, and may not be duplicated or used by any other party without the express consent of the sender. If you are not the intended recipient of the Email, please notify the sender immediately by return https://clicktime.symantec.com/a/1/eICuiPwamVd0HdDhL54mwgyPwL5PbBdtnUw8ZSnbr9E?dH55wJZ44EgrBJUKutH8FokRhE9lhgYepMUofQb9yENyrJCvzyKojgW6vxaqIN6uqNLVwhqJzOvAzKhcW65QoNRPZevq9M3YSmHKUqaDHpt8ZTnXREj0wzj4AyUbCCSXyuk1BlbP_3Jc17L8e2soFFVROefIrlwITwVQL0v5G82PbcVNkUF3U9dXWcqnGoLKoRMHxaG_pOWDjX4yNS9mr42HYpDpLqs-o_43vPDvU2sjE_hFYvCNeLKXQ2hCoMMZR_jqZCRkGUzZ3iynRkipk20gwDbPub-l-MiltIAUVzOqbb_d6LBU5_ZCdUTM4qPwpRAPfNV5O0bG5VDMRizm1ewKBhLineMOfzLnhkdbwnRFiIEbTlau8SIqtT_lE6uPzR_JFedRhmAIgRBSEQYNDL1VCiu1KD2csRS-32323wYGzyR9fw0HWFCLtVrx06PowHtpQl72U0l4%3D&uemail%2C%20delete%20the%20Email%2C%20and%20do not copy, print, retransmit, store or act in reliance on the Email. St Vincent’s Health Australia (“SVHA”) does not guarantee that the Email is free from errors, viruses or interference. Emails to and from SVHA or its related entities may be scanned and filtered in locations outside Australia.
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    #74723
    Matthias Maiwald (SHHQ)
    Participant

    Author:
    Matthias Maiwald (SHHQ)

    Email:
    matthias.maiwald@SINGHEALTH.COM.SG

    Organisation:

    State:

    Hi Both,

    I am far from an expert in this area, but wouldn’t one expect that blood, if it stagnates for a while, will coagulate, and one wouldn’t want to push the blood clot back into the patient?

    Best regards, Matthias.


    Matthias Maiwald, MD, FRCPA
    Senior Consultant in Microbiology
    Head of Service, Microbiology
    Adj. Assoc. Prof., Natl. Univ. Singapore
    Department of Pathology and Laboratory Medicine
    KK Women’s and Children’s Hospital
    100 Bukit Timah Road
    Singapore 229899
    Tel. +65 6394 8725 (Office)
    Tel. +65 6394 1389 (Laboratory)
    Fax +65 6394 1387

    Hi Sonja

    I can’t say that I am an expert in this area, but in our PICC policy it states this:

    If the PICC has not been accessed for 7 days access the PICC with an empty 10ml syringe. Remove 5mls of blood and discard. Then flush with Normal saline 10mls.

    Not sure exactly why that is in there, as our PICC policy is based on The Queensland Health PICC guidelines (https://www.health.qld.gov.au/__data/assets/pdf_file/0028/444493/icare-pcvc-guideline.pdf) and I cannot see this statement in there.

    Not sure if this helps or not!

    Cheers
    Michael

    Michael Wishart, CICP-E
    Infection Control Coordinator

    A 627 Rode Road, Chermside QLD 4032
    P (07) 3326 3068 | F (07) 3607 2226 | E michael.wishart@svha.org.au | W http://www.hsnph.org.au
    [cid:image001.png@01D01926.61F1C2B0] [cid:image002.png@01D42997.357FB770]
    P Please consider the environment before printing this email

    Hello,

    We are reviewing our central line management policies and we trying to find evidence related to the routine practice for aspiration of blood prior to accessing the central line (especially PICC).
    Our ICU team states that this is routinely performed within oncology groups.

    I would be grateful for some specialist information.

    Kind Regards
    Sonja

    Sonja Wegert | Infection Control Practitioner (ICP)
    Infection Prevention and Control Unit | Central Australia Health Service
    Northern Territory Government
    Alice Springs Hospital, Gap Rd, Alice Springs
    GPO Box 2234, Suburb, NT Postcode
    p … 08 89517977
    e … sonja.wegert@nt.gov.au http://www.nt.gov.au/health

    ______________________________________________________________________
    This email and any attachments to it (the “Email”) is confidential and is for the use only of the intended recipient, and may not be duplicated or used by any other party without the express consent of the sender. If you are not the intended recipient of the Email, please notify the sender immediately by return https://clicktime.symantec.com/a/1/eICuiPwamVd0HdDhL54mwgyPwL5PbBdtnUw8ZSnbr9E?dH55wJZ44EgrBJUKutH8FokRhE9lhgYepMUofQb9yENyrJCvzyKojgW6vxaqIN6uqNLVwhqJzOvAzKhcW65QoNRPZevq9M3YSmHKUqaDHpt8ZTnXREj0wzj4AyUbCCSXyuk1BlbP_3Jc17L8e2soFFVROefIrlwITwVQL0v5G82PbcVNkUF3U9dXWcqnGoLKoRMHxaG_pOWDjX4yNS9mr42HYpDpLqs-o_43vPDvU2sjE_hFYvCNeLKXQ2hCoMMZR_jqZCRkGUzZ3iynRkipk20gwDbPub-l-MiltIAUVzOqbb_d6LBU5_ZCdUTM4qPwpRAPfNV5O0bG5VDMRizm1ewKBhLineMOfzLnhkdbwnRFiIEbTlau8SIqtT_lE6uPzR_JFedRhmAIgRBSEQYNDL1VCiu1KD2csRS-32323wYGzyR9fw0HWFCLtVrx06PowHtpQl72U0l4%3D&uemail%2C%20delete%20the%20Email%2C%20and%20do not copy, print, retransmit, store or act in reliance on the Email. St Vincent’s Health Australia (“SVHA”) does not guarantee that the Email is free from errors, viruses or interference. Emails to and from SVHA or its related entities may be scanned and filtered in locations outside Australia.
    MESSAGES POSTED TO THIS LIST ARE SOLELY THE OPINION OF THE AUTHOR, AND DO NOT REPRESENT THE OPINION OF ACIPC.

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    [cid:imaged6dc6e.GIF@6460fad3.468f2d3b]shstagl1

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    #74724
    Cath Murphy
    Participant

    Author:
    Cath Murphy

    Email:
    cath@INFECTIONCONTROLPLUS.COM.AU

    Organisation:

    State:

    Dear Sonja

    The US INS Standards are world class and in Standard 40. Flushing and Locking the procedures are discussed in detail. See below.

    I recall at a recent conference(s) dedicated to vascular access devices there was discussion and I believe a general consensus that blood should not be discarded. In paediatrics specifically repeated discards can lead to loss of blood volume and Hb.

    Within hours I am sure Tim Spencer, Claire Rickard and perhaps even Tricia Kleidon may weigh in on this discussion. In the interim I will look for the references and hopefully it may help you.

    Cath

    Cathryn Murphy RN B. Photog MPH FSHEA FAPIC CIPC-E PhD CIC
    Chief Executive Officer & Creative Director
    Infection Control Plus Pty Ltd
    Adjunct Assoc. Professor – Faculty of Health Services & Medicine
    Bond University
    QLD, Australia

    E: Cath@infectioncontrolplus.com.au
    M: +61 428 154154
    W:http://www.infectioncontrolplus.com.au

    Standard
    40.1 Vascular access devices (VADs) are flushed and
    aspirated for a blood return prior to each infusion to
    assess catheter function and prevent complications.
    40.2 VADs are flushed after each infusion to clear the
    infused medication from the catheter lumen, thereby
    reducing the risk of contact between incompatible
    medications.
    40.3 The VAD is locked after completion of the final
    flush to decrease the risk of intraluminal occlusion and
    catheter-related bloodstream infection (CR-BSI),
    depending on the solution used.
    Practice Criteria
    A. Use single-dose systems (eg, single-dose vials or prefilled
    labeled syringes) for all VAD flushing and
    locking.
    1. Commercially available prefilled syringes may
    reduce the risk of CR-BSI and save staff time for
    syringe preparation. 1-3 (IV)
    2. If multiple-dose vials must be used, dedicate a
    vial to a single patient (see Standard 49,
    Infection ). 4 (V)
    3. Do not use intravenous (IV) solution containers
    (eg, bags or bottles) as a source for obtaining
    flush solutions. 3-6 (IV)
    4. Inform patients that disturbances in taste and
    odor may occur with prefilled flush syringes and
    may be related to several causes including systemic
    conditions (eg, diabetes, Crohn’s disease),
    medications (eg, antineoplastics), and radiation.
    Leaching of substances from the plastic syringe
    into the saline has been reported, although it is
    not thought to be harmful to health. 7-9 (II)
    B. Perform disinfection of connection surfaces (ie,
    needleless connectors, injection ports) before flushing
    and locking procedures (refer to Standard 34,
    Needleless Connectors ).
    C. Flush all VADs with preservative-free 0.9% sodium
    chloride (USP).
    1. Use a minimum volume equal to twice the internal
    volume of the catheter system (eg, catheter
    plus add-on devices). Larger volumes (eg, 5 mL
    for peripheral VAD, 10 mL for central vascular
    access devices [CVADs]) may remove more fibrin
    deposits, drug precipitate, and other debris from
    the lumen. Factors to consider when choosing
    the flush volume include the type and size of
    catheter, age of the patient, and type of infusion
    therapy being given. Infusion of blood components,
    parenteral nutrition, contrast media, and
    other viscous solutions may require larger flush
    volumes. 10 (IV)
    2. If bacteriostatic 0.9% sodium chloride is used,
    limit flush volume to no more than 30 mL in a
    24-hour period to reduce the possible toxic
    effects of the preservative, benzyl alcohol. 11 (V)
    3. Use only preservative-free solutions for flushing
    all VADs in neonates to prevent toxicity. 12 (V)
    4. Use 5% dextrose in water followed by preservative-
    free 0.9% sodium chloride (USP) when the
    medication is incompatible with sodium chloride.
    Do not allow dextrose to reside in the catheter
    lumen as it provides nutrients for biofilm
    growth. 13 (V)
    5. Do not use sterile water for flushing VADs. 14 (V)
    D. Assess VAD functionality by using a 10-mL syringe
    or a syringe specifically designed to generate lower
    injection pressure (ie, 10-mL-diameter syringe barrel),
    taking note of any resistance.
    1. During the initial flush, slowly aspirate the VAD
    for blood return that is the color and consistency
    of whole blood, which is an important
    component of assessing catheter function prior
    to administration of medications and solutions
    (refer to Standard 48, Central Vascular Access
    Device [CVAD] Occlusion ; Standard 53,
    Central Vascular Access Device [CVAD]
    Malposition ).
    2. Do not forcibly flush any VAD with any syringe
    size. If resistance is met and/or no blood return
    noted, take further steps (eg, checking for closed
    clamps or kinked sets, removing dressing, etc.) to
    locate an external cause of the obstruction.
    Internal causes may require diagnostic tests,
    including, but not limited to, a chest radiograph
    to confirm tip location and mechanical causes
    (eg, pinch-off syndrome), color duplex ultrasound,
    or fluoroscopy to identify thrombotic
    causes (see Standard 52, Central Vascular Access
    Device [CVAD]-Associated Venous Thrombosis ;
    Standard 53, Central Vascular Access Device
    [CVAD] Malposition ). 10 (IV)
    3. After confirmation of patency by detecting no
    resistance and the presence of a blood return, use
    syringes appropriately sized for the medication
    being injected. Do not transfer the medication to
    a larger syringe. 3,15 (V)
    4. Do not use prefilled flush syringes for dilution of
    medications. Differences in gradation markings,
    an unchangeable label on prefilled syringes,
    partial loss of the drug dose, and possible contamination
    increase the risk of serious medication
    errors with syringe-to-syringe drug
    transfer. 3,16 (V)
    E. Following the administration of an IV push medication,
    flush the VAD lumen with preservative-free
    0.9% sodium chloride (USP) at the same rate of
    injection as the medication. Use an amount of flush
    solution to adequately clear the medication from the
    lumen of the administration set and VAD. 3 (V)
    F. Use positive-pressure techniques to minimize blood
    reflux into the VAD lumen.
    1. Prevent syringe-induced blood reflux by leaving
    a small amount (eg, 0.5-1 mL) of flush solution
    in a traditional syringe (ie, not a prefilled syringe)
    to avoid compression of the plunger rod gasket
    or by using a prefilled syringe designed to prevent
    this type of reflux. 10,17 (IV)
    2. Prevent disconnection reflux by using the appropriate
    sequence for flushing, clamping, and disconnection
    determined by the type of needleless
    connector being used (refer to Standard 34,
    Needleless Connectors ).
    3. Consider using pulsatile flushing technique. In
    vitro studies have shown that 10 short boluses
    of 1 mL interrupted by brief pauses may be
    more effective at removing solid deposits (eg,
    fibrin, drug precipitate, intraluminal bacteria),
    compared to continuous low-flow techniques.
    Clinical studies are needed to provide more
    clarity on the true effect of this technique. 10,18
    (IV)
    4. When feasible, consider orienting the bevel of an
    implanted port access needle in the opposite
    direction from the outflow channel where the
    catheter is attached to the port body. In vitro testing
    demonstrates a greater amount of protein is
    removed when flushing with this bevel orientation.
    19 (IV)
    G. Lock short peripheral catheters immediately
    following each use.
    1. In adults, use preservative-free 0.9% sodium
    chloride (USP) for locking. 10,20-24 (I)
    2. In neonates and pediatrics, use heparin 0.5 units
    to 10 units per mL or preservative-free 0.9%
    sodium chloride (USP). Outcome data in these
    patient populations are controversial. 25,26 (II)
    3. For short peripheral catheters not being used for
    intermittent infusion, consider locking once every
    24 hours. 27 (III)
    H. There is insufficient evidence to recommend the
    solution for locking midline catheters.
    I. Lock CVADs with either heparin 10 units per mL or
    preservative-free 0.9% sodium chloride (USP),
    according to the directions for use for the VAD and
    needleless connector.
    1. Establish a standardized lock solution for each
    patient population, organization-wide. 28,29 (V)
    2. Randomized controlled trials have shown equivalent
    outcomes with heparin and sodium chloride
    lock solutions for multiple-lumen nontunneled
    CVADs, peripherally inserted central catheters
    (PICCs), and implanted ports while accessed
    and when the access needle is removed. There is
    insufficient evidence to recommend one lock
    solution over the other. 30-33 (I)
    3. Use heparin or preservative-free 0.9% sodium
    chloride (USP) for locking CVADs in children. 29
    (II)
    4. Consider using heparin 10 units per mL for locking
    PICCs in home care patients. 34 (III)
    5. Volume of the lock solution should equal the
    internal volume of the VAD and add-on devices
    plus 20%. Flow characteristics during injection
    will cause overspill into the bloodstream. Lock
    solution density is less than whole blood, allowing
    leakage of lock solution and ingress of blood
    into the catheter lumen when the CVAD tip location
    is higher than the insertion site. 10,35-37 (IV)
    6. Change to an alternative locking solution when
    the heparin lock solution is thought to be the
    cause of adverse drug reactions from heparin;
    when heparin-induced thrombocytopenia and
    thrombosis (HITT) develops; and when there are
    spurious laboratory studies drawn from the
    CVAD that has been locked with heparin. High
    concentrations of heparin used in hemodialysis
    catheters could lead to systemic anticoagulation.
    Heparin-induced thrombocytopenia (HIT) has
    been reported with the use of heparin lock solutions,
    although the exact rates are unknown (see
    Standard 43, Phlebotomy ). 11,38 (II)
    7. Monitoring platelet counts for HIT is not recommended
    in postoperative and medical patients
    receiving only heparin in the form of a catheter
    lock solution due to a very low incidence of HIT
    of 1% or less (see Standard 52, Central Vascular
    Access Device [CVAD] – Associated Venous
    Thrombosis ). 38 (II)
    8. Because of conflicts with religious beliefs, inform
    patients when using heparin derived from animal
    products (eg, porcine, bovine), and obtain consent.
    Use preservative-free 0.9% sodium chloride
    (USP) instead of heparin when possible. 39 (V)
    J. Lock hemodialysis CVADs with heparin lock solution
    1000 units/mL, 4% citrate, or antimicrobial
    lock solutions. Use recombinant tissue plasminogen
    activator to lock hemodialysis catheters once per
    week as a strategy to reduce CR-BSI. 40-43 (I)
    K. Lock apheresis CVADs with heparin 100 units/mL,
    4% citrate, acid-citrate-dextrose Formula A, or
    other antimicrobial lock solutions. 40-42,44,45 (IV)
    L. Use solution containing heparin (eg, 1 unit per mL
    of 0.9% sodium chloride [USP]) or preservative-free
    0.9% sodium chloride (USP) as a continuous flow to
    maintain patency of arterial catheters used for
    hemodynamic monitoring. The decision to use preservative-
    free 0.9% sodium chloride (USP) instead
    of heparin infusion should be based on the clinical
    risk of catheter occlusion, the anticipated length of
    time the arterial catheter will be required, and
    patient factors such as heparin sensitivities. 46-48 (II)
    M. Apply the following recommendations for neonates
    and pediatrics.
    1. Use a continuous infusion of heparin 0.5 units
    per kg for all CVADs in neonates.
    2. Use continuous infusion of heparin 0.25 to 1 unit
    per mL (total dose of heparin 25-200 units per kg
    per day) for umbilical arterial catheters in neonates
    to prevent arterial thrombosis.
    3. Use heparin 5 units per mL, 1 mL per hour as a
    continuous infusion for neonates and children
    with peripheral arterial catheters (see Standard
    30, Umbilical Catheters ). 29 (II)
    N. Use antimicrobial locking solutions for therapeutic
    and prophylactic purposes. Use in patients with
    long-term CVADs, patients with a history of multiple
    CR-BSIs, high-risk patient populations, and in
    facilities with unacceptably high rates of central lineassociated
    bloodstream infection (CLABSI), despite
    application of other methods of CLABSI reduction.
    42,49-52 (I)
    1. Antibiotic lock solutions contain supratherapeutic
    concentrations of antibiotics and may be
    combined with heparin. Anticipate the chosen
    antibiotic to be based on the specific infecting
    organism or on prevalent organisms within the
    organization when prophylaxis is the goal. For
    therapeutic use, start the antibiotic lock solutions
    within 48 to 72 hours of diagnosis; however, the
    duration of use remains controversial. 53 (II)
    2. Antiseptic locking solutions include ethanol,
    taurolidine, citrate, 26% sodium chloride,
    methylene blue, fusidic acid, and ethylenediaminetetra-
    acetic acid (EDTA) used alone or in
    numerous combinations. 51 (I)
    3. Follow catheter manufacturers’ instructions for
    intraluminal locking with ethanol. Changes in
    CVADs made of polyurethane material, but not
    silicone, have led to catheter rupture and splitting.
    Monitor for thrombotic lumen occlusion as
    ethanol has no anticoagulant activity, hemolysis,
    and hepatic toxicity. Irreversible precipitation of
    plasma proteins that could add to CVAD lumen
    occlusion is associated with ethanol concentrations
    greater than 28%. 37,54-56 (I)
    4. Monitor sodium citrate, an anticoagulant with
    antimicrobial effects, for systemic anticoagulation,
    hypocalcemia that could produce cardiac
    arrest, and protein precipitate formation with
    concentrations greater than 12%. 36,43 (I)
    5. Monitor taurolidine, an amino acid with antimicrobial
    effects, for thrombotic lumen occlusion
    and protein precipitation, which could cause
    lumen occlusion. 30,51,57 (I)
    6. Use standardized formulations and licensed independent
    practitioner (LIP)-approved protocols
    for all antimicrobial lock solutions to enhance
    patient safety. Consult with pharmacy when
    combinations of antimicrobial solutions are
    planned so that correct information about compatibility
    and stability of the solution are
    addressed. 53,58 (II)
    7. The length of time that antimicrobial lock solutions
    should reside inside the CVAD lumen is
    unclear; up to 12 hours per day may be required.
    This will limit use in patients receiving continuous
    or frequent intermittent infusions. 53 (II)
    8. Aspirate all antimicrobial locking solutions from
    the CVAD lumen at the end of the locking period.
    Do not flush the lock solution into the
    patient’s bloodstream, as this could increase
    development of antibiotic resistance and other
    adverse effects. Gentamicin-resistant bacteria
    from gentamicin lock solution have been reported
    to increase CLABSI rates. 42,58,59 (II)

    Hello,

    We are reviewing our central line management policies and we trying to find evidence related to the routine practice for aspiration of blood prior to accessing the central line (especially PICC).
    Our ICU team states that this is routinely performed within oncology groups.

    I would be grateful for some specialist information.

    Kind Regards
    Sonja

    Sonja Wegert | Infection Control Practitioner (ICP)
    Infection Prevention and Control Unit | Central Australia Health Service
    Northern Territory Government
    Alice Springs Hospital, Gap Rd, Alice Springs
    GPO Box 2234, Suburb, NT Postcode
    p … 08 89517977
    e … sonja.wegert@nt.gov.au http://www.nt.gov.au/health

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